ZNF408 Antibody / PRDM17

Flow cytometry: 1-2ug/million cells,Western blot: 1-2ug/ml

Optimal dilution of the ZNF408 antibody should be determined by the researcher.

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Kr ppel C2H2-type zinc-finger protein family, ZNF396 (zinc finger protein 396), also known as PRDM17 (PR domain zinc finger protein 17), is a 720 amino acid nuclear protein that contains ten C2H2-type zinc fingers. The gene encoding ZNF408 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Recombinant full-length human ZNF408 protein was used as the immunogen for the ZNF408 antibody.

This ZNF408 antibody is available for research use only.

Nucleus

Protein A/G affinity

Q9H9D4