Elabscience

Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active)

Product Code:
 
PKSH030428
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
 
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
 

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PKSH030428-50ug50ug£652.00
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Further Information

Abbreviation:
EGFR;ErbB1
Accession:
NP_005219
Activity:
The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
Background:
As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.
Calculated MW:
89.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
Baculovirus-Insect Cells
Formulation:
Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His-GST
Purity:
> 85 % as determined by reducing SDS-PAGE.
Sequence:
Met 668-Ala 1210
Target Synonym:
ERBB;ERBB1;HER1;mENA;NISBD2;PIG61

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