Elabscience

KLHDC2 Polyclonal Antibody

Product Code:
 
E-AB-93134
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of K-562 cells using KLHDC2 Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of K-562 cells using KLHDC2 Polyclonal Antibody at 1:1000 dilution.

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E-AB-93134-60uL60uL£210.00
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E-AB-93134-120uL120uL£291.00
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E-AB-93134-200uL200uL£431.00
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Further Information

Abbreviation:
KLHDC2
Background:
Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2 complex specifically recognizes proteins with a diglycine (Gly-Gly at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2 complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2 complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
28kDa/46kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human KLHDC2
ObservedMW:
46kDa
Purification method:
Affinity purification
Target Synonym:
KLHDC2;HCLP-1;HCLP1;LCP
UNIProt ID:
Q9Y2U9

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