Elabscience

VHL Polyclonal Antibody

Product Code:
 
E-AB-93053
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using VHL Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using VHL Polyclonal Antibody at 1:1000 dilution.

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CodeSizePrice
E-AB-93053-60uL60uL£210.00
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E-AB-93053-120uL120uL£291.00
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E-AB-93053-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
VHL
Background:
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
18kDa/19kDa/24kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
A synthetic peptide of human VHL
ObservedMW:
18kDa, 24kDa
Purification method:
Affinity purification
Target Synonym:
VHL;HRCA1;RCA1;VHL1;pVHL;PVHL
UNIProt ID:
P40337

Documents