Elabscience

p53 DINP1 Polyclonal Antibody

Product Code:
 
E-AB-92850
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using p53 DINP1 Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using p53 DINP1 Polyclonal Antibody at 1:1000 dilution.

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E-AB-92850-60uL60uL£210.00
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E-AB-92850-120uL120uL£291.00
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E-AB-92850-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
p53 DINP1
Background:
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
18kDa/27kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
A synthetic peptide of human p53 DINP1
ObservedMW:
32kDa
Purification method:
Affinity purification
Target Synonym:
TP53INP1;SIP;TP53DINP1;TP53INP1A;TP53INP1B;Teap;p53DINP1
UNIProt ID:
Q96A56

Documents