Elabscience

CDK12 Polyclonal Antibody

Product Code:
 
E-AB-90992
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of Mouse brain using CDK12 Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of Mouse brain using CDK12 Polyclonal Antibody at 1:1000 dilution.

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E-AB-90992-60uL60uL£210.00
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E-AB-90992-120uL120uL£291.00
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E-AB-90992-200uL200uL£431.00
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Further Information

Abbreviation:
CDK12
Background:
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
141kDa/163kDa/164kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human CDK12
ObservedMW:
205KDa
Purification method:
Affinity purification
Target Synonym:
CDK12;CRK7;CRKR;CRKRS
UNIProt ID:
Q9NYV4

Documents