Elabscience

(KO Validated) HIF1AN Polyclonal Antibody

Product Code:
 
E-AB-68371
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts from normal (control) and HIF1AN/FIH1 antibody knockout (KO) 293T cells, using HIF1AN/FIH1 antibody at 1:1000 dilution.
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Western blot analysis of extracts from normal (control) and HIF1AN/FIH1 antibody knockout (KO) 293T cells, using HIF1AN/FIH1 antibody at 1:1000 dilution.

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CodeSizePrice
E-AB-68371-60uL60uL£224.00
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E-AB-68371-120uL120uL£317.00
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E-AB-68371-200uL200uL£465.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
HIF1AN
Background:
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
40kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human HIF1AN
ObservedMW:
40kDa
Purification method:
Affinity purification
Target Synonym:
HIF1AN;FIH1
UNIProt ID:
Q9NWT6

Documents