Elabscience

NCF4 Polyclonal Antibody

Product Code:
 
E-AB-68341
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines using NCF4/p40-phox Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using NCF4/p40-phox Polyclonal Antibody at 1:1000 dilution.

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E-AB-68341-60uL60uL£210.00
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E-AB-68341-120uL120uL£291.00
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E-AB-68341-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
NCF4
Background:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
39kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human NCF4
ObservedMW:
40KDa
Purification method:
Affinity purification
Target Synonym:
NCF4;CGD3;NCF;P40PHOX;SH3PXD4
UNIProt ID:
Q15080

Documents