Elabscience

p53RFP Polyclonal Antibody

Product Code:
 
E-AB-15118
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
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Immunohistochemistry of paraffin-embedded Human lung cancer using p53RFP Polyclonal Antibody at dilution of 1:50
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Immunohistochemistry of paraffin-embedded Human cervical cancer using p53RFP Polyclonal Antibody at dilution of 1:50

Immunohistochemistry of paraffin-embedded Human lung cancer using p53RFP Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human cervical cancer using p53RFP Polyclonal Antibody at dilution of 1:50

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E-AB-15118-20uL20uL£125.00
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E-AB-15118-60uL60uL£172.00
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E-AB-15118-120uL120uL£237.00
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E-AB-15118-200uL200uL£344.00
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This product comes from: China.
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Further Information

Abbreviation:
RNF144B
Background:
p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
34kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000, IHC 1:50-1:200
Immunogen:
Recombinant protein of human RNF144B
Purification method:
Affinity purification
Target Synonym:
bA528A10.3;E3 ubiquitin protein ligase RNF144B;E3 ubiquitin-protein ligase RNF144B;IBR domain containing 2;IBR domain containing protein 2;IBR domain-containing protein 2;IBRDC 2;IBRDC2;KIAA0161;MGC71786;OTTHUMP00000016079;OTTHUMP00000016080;OTTHUMP00000039360;p53 inducible RING finger protein;p53-inducible RING finger protein;p53RFP;PIR2;R144B;Ring finger 144B;RING finger protein 144B;RNF 144B;RNF144B
UNIProt ID:
Q7Z419

Documents