Elabscience

Recombinant Human ALK-1/ACVRL1 Protein (His Tag)(Active)

Product Code:
 
PKSH031898
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Cell Culture
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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CodeSizePrice
PKSH031898-100ug100ug£615.00
Quantity:
PKSH031898-1mg1mg£3,588.00
Quantity:
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This product comes from: China.
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Further Information

Abbreviation:
ALK-1;ACVRL1
Accession:
NP_000011.2
Activity:
Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 50-200 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
Background:
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Calculated MW:
12.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
27 kDa
Purity:
> 92 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Gln 118
Target Synonym:
Serine/Threonine-Protein Kinase Receptor R3;SKR3;Activin Receptor-Like Kinase 1;ALK-1;TGF-B Superfamily Receptor Type I;TSR-I;ACVRL1;ACVRLK1;ALK1;HHT;HHT2;ORW2;SKR3

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