Elabscience

ERK 1/2 Monoclonal Antibody

Product Code:
 
E-AB-22172
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
6B1
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western Blot analysis of 1) Mouse brain, 2) Rat brain using ERK 1/2 Monoclonal Antibody at dilution of 1:2000.
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Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using ERK 1/2 Monoclonal Antibody at dilution of 1:200.
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Western Blot analysis of 1) Mouse brain, 2) Rat brain using ERK 1/2 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using ERK 1/2 Monoclonal Antibody at dilution of 1:200.

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E-AB-22172-20uL20uL£125.00
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E-AB-22172-60uL60uL£172.00
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E-AB-22172-120uL120uL£237.00
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E-AB-22172-200uL200uL£344.00
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Further Information

Abbreviation:
P44/42 MAPK (ERK1/2)
Background:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-2000, IHC 1:50-100
Immunogen:
Synthetic Peptide
ObservedMW:
44,42kDa
Purification method:
Protein A purification
Target Synonym:
MAPK3;ERK1;PRKM3;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p
UNIProt ID:
P27361,P28482

Documents