Elabscience

CRACR2A Polyclonal Antibody

Product Code:
 
E-AB-64839
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human colon using CRACR2A Polyclonal Antibody at dilution of 1:150 (40x lens).
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Immunohistochemistry of paraffin-embedded Mouse spleen using CRACR2A Polyclonal Antibody at dilution of 1:150 (40x lens).
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Immunohistochemistry of paraffin-embedded Human colon using CRACR2A Polyclonal Antibody at dilution of 1:150 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse spleen using CRACR2A Polyclonal Antibody at dilution of 1:150 (40x lens).

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E-AB-64839-60uL60uL£210.00
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E-AB-64839-120uL120uL£291.00
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E-AB-64839-200uL200uL£431.00
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Further Information

Abbreviation:
CRACR2A
Background:
Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
45kDa/83kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human CRACR2A (NP_001138430.1).
ObservedMW:
45kDa
Purification method:
Affinity purification
Target Synonym:
CRACR2A;EFCAB4B
UNIProt ID:
Q9BSW2

Documents