Elabscience

JUN Polyclonal Antibody

Product Code:
 
E-AB-70029
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry analysis of paraffin-embedded human liver cancer using JUN Polyclonal Antibody at dilution of 1:500.
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Immunohistochemistry analysis of paraffin-embedded human liver cancer using JUN Polyclonal Antibody at dilution of 1:500.

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E-AB-70029-60uL60uL£184.00
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E-AB-70029-120uL120uL£251.00
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E-AB-70029-200uL200uL£351.00
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Further Information

Abbreviation:
JUN
Background:
JUN is also named as c-Jun and AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
1.15 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:500-1:2000
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse c- JUN
Purification method:
Affinity purification
Target Synonym:
Activator protein 1;AP 1;AP1;cJun;Enhancer Binding Protein AP1;Jun Activation Domain Binding Protein;JUN;Jun oncogene;JUN protein;Jun proto oncogene;JUN;JUNC;Oncogene JUN;p39;Proto oncogene c jun;Proto oncogene cJun;Proto-oncogene c-jun;Transcription Factor AP 1;Transcription factor AP-1;Transcription Factor AP1;V jun avian sarcoma virus 17 oncogene homolog;V jun sarcoma virus 17 oncogene homolog (avian);V jun sarcoma virus 17 oncogene homolog;V-jun avian sarcoma virus 17 oncogene homolog;vJun Avian Sarcoma Virus 17 Oncogene Homolog
UNIProt ID:
P05412,P05627,P17325

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