Elabscience

PMS2 Polyclonal Antibody

Product Code:
 
E-AB-64786
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunofluorescence (IF)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunofluorescence analysis of U2OS cells using PMS2 Polyclonal Antibody
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Immunofluorescence analysis of U2OS cells using PMS2 Polyclonal Antibody

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CodeSizePrice
E-AB-64786-60uL60uL£224.00
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E-AB-64786-120uL120uL£317.00
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E-AB-64786-200uL200uL£465.00
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This product comes from: China.
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Further Information

Abbreviation:
PMS2
Background:
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human PMS2 (NP_000526.2).
Purification method:
Affinity purification
Target Synonym:
PMS2;HNPCC4;MLH4;PMS2CL;PMSL2
UNIProt ID:
P54278

Documents