Elabscience

RAD17 Polyclonal Antibody

Product Code:
 
E-AB-60923
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines using RAD17 Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using RAD17 Polyclonal Antibody at 1:1000 dilution.

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CodeSizePrice
E-AB-60923-60uL60uL£210.00
Quantity:
E-AB-60923-120uL120uL£291.00
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E-AB-60923-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
RAD17
Background:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
57kDa/66kDa/75kDa/77kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human RAD17
ObservedMW:
77kDa
Purification method:
Affinity purification
Target Synonym:
RAD17;CCYC;HRAD17;R24L;RAD17SP;RAD24
UNIProt ID:
O75943

Documents