Elabscience

SIRT1 Polyclonal Antibody

Product Code:
 
E-AB-70368
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry analysis of paraffin-embedded mouse brain using SIRT1 Polyclonal Antibody at dilution of 1:300.
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Immunohistochemistry analysis of paraffin-embedded mouse brain using SIRT1 Polyclonal Antibody at dilution of 1:300.

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Further Information

Abbreviation:
SIRT1
Background:
SIRT1,also named as SIR2L1,contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection,including: activation of endothelial nitric oxide synthase,insulin receptor signalling,and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO,Hif-2a,and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53,specifically at Lysine 382.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration:
1.2 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:200-1:600
Immunogen:
Recombinant protein corresponding to Mouse SIRT1
Purification method:
Affinity purification
Target Synonym:
75SirT1;hSIR2;hSIRT1;HST2;S. cerevisiae;homolog of;NAD dependent deacetylase sirtuin 1;NAD dependent protein deacetylase sirtuin 1;OTTHUMP00000198111;OTTHUMP00000198112;Regulatory protein SIR2 homolog 1;SIR1;SIR2;SIR2 like 1;SIR2 like protein 1;SIR2;S.cerevisiae;homolog-like 1;SIR2-like protein 1;SIR2ALPHA;SIR2L1;Sirt1;SirtT1 75 kDa fragment;Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1;Sirtuin type 1
UNIProt ID:
Q923E4

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