Elabscience

Recombinant Human Kininogen 1/KNG1 Protein (His Tag)

Product Code:
 
PKSH033413
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 

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CodeSizePrice
PKSH033413-10ug10ug£219.00
Quantity:
PKSH033413-50ug50ug£497.00
Quantity:
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This product comes from: China.
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Further Information

Abbreviation:
Kininogen 1;KNG1
Accession:
NP_001095886.1
Background:
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn?t involved in blood clotting.
Calculated MW:
46.9 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM Hac-NaAC, 150mM NaCl, pH 4.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
61 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Gln19-Ser427
Target Synonym:
Kininogen-1;lpha-2-Thiol Proteinase Inhibitor;Fitzgerald Factor;High Molecular Weight Kininogen;HMWK;Williams-Fitzgerald-Flaujeac Factor;KNG1;BDK;KNG

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