Elabscience

SMC1A Polyclonal Antibody

Product Code:
 
E-AB-18291
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human breast cancer tissue using SMC1A Polyclonal Antibody at dilution of 1:45(?200)
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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SMC1A Polyclonal Antibody at dilution of 1:45(?200)
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Immunohistochemistry of paraffin-embedded Human breast cancer tissue using SMC1A Polyclonal Antibody at dilution of 1:45(?200)
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SMC1A Polyclonal Antibody at dilution of 1:45(?200)

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E-AB-18291-20uL20uL£125.00
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E-AB-18291-60uL60uL£172.00
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E-AB-18291-120uL120uL£237.00
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E-AB-18291-200uL200uL£344.00
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Further Information

Abbreviation:
SMC1A
Background:
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.7 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human SMC1A
Purification method:
Antigen affinity purification
Target Synonym:
Chromosome segregation protein SmcB;DXS423E;KIAA0178;MGC138332;Sb1.8;Segregation of mitotic chromosomes 1;SMC protein 1A;SMC-1-alpha;SMC-1A;SMC1 (structural maintenance of chromosomes 1 yeast) like 1;SMC1;SMC1 structural maintenance of chromosomes 1 like 1;SMC1A;SMC1A;SMC1alpha;SMC1L1;SMCB;Structural maintenance of chromosomes 1A;Structural maintenance of chromosomes protein 1A
UNIProt ID:
Q14683

Documents