Elabscience

GCLC Polyclonal Antibody

Product Code:
 
E-AB-52359
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
1 / 2
Western blot analysis of Raw264.7 A549 Hepg2 and Jurkat cell using GCLC Polyclonal Antibody at dilution of 1:800
2 / 2
Immunohistochemistry of paraffin-embedded Human brain tissue using GCLC Polyclonal Antibody at dilution of 1:35(?200)
❮❯

Western blot analysis of Raw264.7 A549 Hepg2 and Jurkat cell using GCLC Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffin-embedded Human brain tissue using GCLC Polyclonal Antibody at dilution of 1:35(?200)

No additional charges, what you see is what you pay! *

CodeSizePrice
E-AB-52359-20uL20uL£125.00
Quantity:
E-AB-52359-60uL60uL£172.00
Quantity:
E-AB-52359-120uL120uL£237.00
Quantity:
E-AB-52359-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: China.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Abbreviation:
GCLC
Background:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
73 kDa
Concentration:
0.8 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human GCLC
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
EC 6.3.2.2;Gamma ECS;Gamma glutamylcysteine synthetase;Gamma-ECS;Gamma-glutamylcysteine synthetase;GCL;Gclc;GCS;GCS heavy chain;GLCL;GLCLC;Glutamate cysteine ligase catalytic subunit;Glutamate--cysteine ligase catalytic subunit;GSH1
UNIProt ID:
P48506

Documents

References

  • https://www.sciencedirect.com/science/article/pii/S2213231721002007
  • https://www.mdpi.com/1170076