Elabscience

EIF3C Polyclonal Antibody

Product Code:
 
E-AB-52777
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human tonsil tissue using EIF3C Polyclonal Antibody at dilution of 1:35(?200)
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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using EIF3C Polyclonal Antibody at dilution of 1:35(?200)
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Immunohistochemistry of paraffin-embedded Human tonsil tissue using EIF3C Polyclonal Antibody at dilution of 1:35(?200)
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using EIF3C Polyclonal Antibody at dilution of 1:35(?200)

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E-AB-52777-20uL20uL£125.00
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E-AB-52777-60uL60uL£172.00
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E-AB-52777-120uL120uL£237.00
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E-AB-52777-200uL200uL£344.00
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Further Information

Abbreviation:
EIF3C
Background:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human EIF3C
Purification method:
Antigen affinity purification
Target Synonym:
Cell migration inducing protein 17;eIF 3c;eIF3 p110;eIF3-p110;eIF3c;EIF3C;EIF3CL;EIF3S8;EIF3S8 protein;Eukaryotic translation initiation factor 3 subunit 8 (110kD);Eukaryotic translation initiation factor 3 subunit 8 110kDa;Eukaryotic translation initiation factor 3 subunit 8;Eukaryotic translation initiation factor 3 subunit C
UNIProt ID:
Q99613

Documents