Elabscience

VEGFA Polyclonal Antibody

Product Code:
 
E-AB-53277
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human cervical cancer tissue  using VEGFA Polyclonal Antibody at dilution of 1:60(?200)

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue  using VEGFA Polyclonal Antibody at dilution of 1:60(?200)

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E-AB-53277-20uL20uL£125.00
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E-AB-53277-60uL60uL£172.00
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E-AB-53277-120uL120uL£237.00
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E-AB-53277-200uL200uL£344.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
VEGFA
Background:
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
27 kDa
Concentration:
1.8 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:5000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human VEGFA
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
Folliculostellate cell-derived growth factor;Glioma-derived endothelial cell mitogen;MGC70609;MVCD1;Vascular endothelial growth factor A;vascular endothelial growth factor A121;vascular endothelial growth factor A165;vascular endothelial growth factor;Vascular permeability factor;VEGF A;Vegf;VEGF-A;VEGF120;Vegfa;VEGFA;VPF
UNIProt ID:
P15692

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