Elabscience

Phospho-AKT1 (Ser473) Monoclonal Antibody

Product Code:
 
E-AB-51038
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Clone:7F9
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western Blot analysis of PC3 cells using Phospho-AKT1 (Ser473) Monoclonal Antibody at dilution of 1:1000.
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Immunohistochemistry of paraffin-embedded Human lung carcinoma tissue using Phospho-AKT1 (Ser473) Monoclonal Antibody at dilution of 1:200.
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Western Blot analysis of PC3 cells using Phospho-AKT1 (Ser473) Monoclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human lung carcinoma tissue using Phospho-AKT1 (Ser473) Monoclonal Antibody at dilution of 1:200.

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E-AB-51038-20uL20uL£125.00
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  • Further Information
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Further Information

Abbreviation:
Phospho-AKT1 (Ser473)
Background:
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-2000, IHC 1:100-200
Immunogen:
Synthetic Peptide of Phospho-Akt (S473)
ObservedMW:
60kDa
Purification method:
Protein A purification
Target Synonym:
AKT 1;AKT;AKT1;AKT1;MGC99656;PKB;PKB-ALPHA;PRKBA;Protein Kinase B Alpha;Protein kinase B;Proto-oncogene c-Akt;RAC Alpha;RAC;RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha
UNIProt ID:
P31749

Documents

References

  • https://www.liebertpub.com/doi/abs/10.1089/ars.2019.7923