Elabscience

ANO1 Polyclonal Antibody

Product Code:
 
E-AB-65774
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Immunofluorescence (IF)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunofluorescence analysis of U2OS cells using ANO1 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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Immunofluorescence analysis of U2OS cells using ANO1 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

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E-AB-65774-60uL60uL£210.00
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E-AB-65774-120uL120uL£291.00
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E-AB-65774-200uL200uL£431.00
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Further Information

Abbreviation:
ANO1
Background:
TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 (anoctamin 1), is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IF 1:100-1:200
Immunogen:
Recombinant fusion protein of human ANO1 (NP_060513.5).
Purification method:
Affinity purification
Target Synonym:
ANO1;DOG1;ORAOV2;TAOS2;TMEM16A
UNIProt ID:
Q5XXA6

Documents