Elabscience

Recombinant HMGB1 Monoclonal Antibody

Product Code:
 
E-AB-81436
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
R07-2D8
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
1 / 2
Western blot detection of HMGB1 in K562,Rat Brain,C6,3T3,Hela cell lysates using HMGB1 Rabbit mAb(1:1000 diluted).Predicted band size:25kDa.Observed band size:25kDa.
2 / 2
Immunohistochemistry of HMGB1 in paraffin-embedded Human tonsil using HMGB1 Rabbit mAb at dilution 1:100
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Western blot detection of HMGB1 in K562,Rat Brain,C6,3T3,Hela cell lysates using HMGB1 Rabbit mAb(1:1000 diluted).Predicted band size:25kDa.Observed band size:25kDa.
Immunohistochemistry of HMGB1 in paraffin-embedded Human tonsil using HMGB1 Rabbit mAb at dilution 1:100

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E-AB-81436-50uL50uL£184.00
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E-AB-81436-100uL100uL£251.00
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Further Information

Abbreviation:
HMGB1
Background:
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
Buffer:
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Calculated MW:
25kDa
Concentration:
300 ug/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:2000 IHC 1:50-1:100
Immunogen:
A synthetic peptide of human HMGB1
ObservedMW:
25kDa
Purification method:
Affinity Purified
Target Synonym:
Amphoterin;Chromosomal protein;nonhistone;HMG1;DKFZp686A04236;High mobility group 1;High mobility group box 1;High mobility group protein 1;High mobility group protein B1;high-mobility group (nonhistone chromosomal) protein 1;HMG-1;HMG1;HMG3;HMGB 1;HMGB1;HMGB1;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein
UNIProt ID:
P09429

Documents