MBL

Anti-CD3e (Mouse) mAb-PE

Product Code:
 
MBL-FP20206010
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Hamster
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
145-2C11
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-FP20206010100 ug£249.00
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Further Information

Background:
The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.
Concentration:
0.2 mg/mL
Conjugate:
PE
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
CD3e

Documents

References

Damoiseaux, J. G., et al., J Leukoc Biol. 64, 803-809 (1998) Maeda, K., et al., Int Immunol. 9, 993-1000 (1997) Bluestone, J. A., Immunity. 2, 555-559 (1995)