MBL

Anti-L-Selectin (CD62L) (Mouse) mAb-FITC

Product Code:
 
MBL-FP20185050
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
MEL-14
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-FP20185050500 ug£354.00
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Further Information

Background:
The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains. The weight of the CD62L molecules depend on their origin, 74 kDa on lymphocytes or 95 kDa on neutrophils. In the mouse organism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils. The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins (MadCAM-1, GLYCAM-1, and CD 34). It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes. After cell activation, it is quickly shed by neutrophils and lymphocytes.
Concentration:
0.5 mg/mL
Conjugate:
FITC
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
L-Selectin

Documents

References

Breviario, F., et al., Arterioscler Thromb Vasc Biol. 15, 1229-1239 (1995) Rajesh, D., et al., Stem Cells. 25, 490-499 (2007) Dejana, E., et al., Exp Cell Res. 252, 13-19 (1999)