MBL

Anti-CD358 (DR6) (Human) mAb

Product Code:
 
MBL-W072-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3E2E4
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-W072-3100 ul£345.00
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  • Further Information
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Further Information

Applications:
FCM - 1-10 ug/mL
Background:
Death receptor 6 (DR6), also known as CD358 or TNFRSF21, is a member of the tumor necrosis factor receptor superfamily. DR6 contains a death domain and four TNFR-Cys repeats. It is highly expressed in the heart, brain, placenta, pancreas, lymph nodes, thymus, and prostate. DR6 activates nuclear factor kappa-B and mitogen-activated protein kinase 8 and induces cell apoptosis. Overexpression of DR6 has been observed in several cancers including ovarian cancer and sarcoma.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 27242
Immunogen Translated:
Human CD358 (DR6) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity:
This antibody reacts with human CD358 (DR6) on Flow cytometry.
Source:
This antibody was purified from hybridoma culture supernatant by Protein A affinity column chromatography.
Target:
CD358 (DR6) (Human)

Documents

References

1) Kojima, T. and Kitamura,T., Nat. Biotechnol. 17, 487-490 (1999) 2) Pan, G., et al., FEBS Lett. 431, 351-356 (1998)