MBL

Anti-NRF2 mAb

Product Code:
 
MBL-M200-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1F2
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-M200-3100 ul£335.00
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  • Further Information
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Further Information

Applications:
WB - 1 μg/mL for chemiluminescence detection system IP - 5 μg /300 μL of cell extract from 3x106 cells ICC - 0.5 μg/mL IHC - 1 μg/mL (praffin section)
Background:
NRF2 is a transcriptional factor and responses to an environmental stress including oxidative condition, together with another oxidative stress sensor, Keap1. Under normal physiological conditions, Keap1 mediates ubiquitination and degradation of NRF2, resulting in low levels of NRF2 in normal cells. It has been reported that one of the?autophagy-related proteins, p62, accumulates in cancer cells and competes interaction?between NRF2 and Keap1, and then NRF2 translocates to nucleus and leads gene expression of NRF2 related-cytoprotective factors, including detoxifying enzymes.
Formulation:
PBS containing 50% Glycerol (pH 7.2)
Gene IDs:
Human: 4780 Mouse: 18024 Rat: 83619
Immunogen Translated:
Human NRF2, full length (recombinant)
Shelf Life:
1 year
Source:
Purified IgG from hybridoma supernatant
Target:
NRF2

Documents

References

Nguyen, T., et al., J. Biol. Chem. 284, 13291-13295 (2009)