MBL

Anti-Rubicon (Human) mAb

Product Code:
 
MBL-M170-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1H6
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-M170-3100 ul£357.00
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Further Information

Applications:
WB - 1 ug/mL (chemiluminescence detection system)
Background:
Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Rubicon was identified as Beclin1 interacting protein. Three distinct Beclin1 complexes exist in cells, one of the complexes including Rubicon (Beclin1, hVps34, hVps15, UVRAG, Rubicon) down regulates the process of autophagosome maturation and endocytosis.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 9711 Mouse: 224118
Immunogen Translated:
Recombinant human Rubicon (722-972 aa)
Reactivity:
This antibody reacts with human Rubicon on Western blotting.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 1H6) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with CH3 mouse lymphocyte immunized with the recombinant human Rubicon (722-972 aa).
Target:
Rubicon

Documents

References

1) Matsunaga, K., et al., Nat. Cell Biol. 11, 385-396 (2009) 2) Zhong, Y., et al., Nat. Cell Biol. 11, 468-476 (2009)