MBL

Anti-Dlk (Pref-1) mAb

Product Code:
 
MBL-D187-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
24-11
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Immunohistochemistry (IHC)
Shipping:
 
4°C
Storage:
 
-20°C
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CodeSizePrice
MBL-D187-3100 ug£301.00
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  • Further Information
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Further Information

Applications:
FCM - 5-10 ug/mL IHC - 10 ug/mL (paraffin), 1 ug/mL (frozen)
Background:
Delta like protein (Dlk), also known as Preadipocyte factor-1 (Pref-1) or zona glomerulosa-specific factor (ZOG), is an EGF-like transmembrane protein expressed preadipocytes but not in mature adipocytes. It is highly expressed in fetal liver, the adrenal gland, and placenta, as well as some neuroendocrine tumors and small cell lung carcinomas, where it plays a role in differentiation and proliferation. Dlk positively and negatively regulates adipocyte differentiation via at least four major variants (45-60 kDa) of Dlk generated by alternatively splicing. Constitutive expression of Dlk inhibits adipogenesis, but insulin or insulin like growth factor-1 (IGF-1) can circumvent this inhibition. Regulated processing of Dlk releases a 50 kDa soluble form that was previously characterized as Fetal Antigen-1, a protein involved in pancreatic island cell differentiation.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
Gene IDs:
Human: 8788 Mouse: 13386
Immunogen Translated:
Pref-1-Fc protein
Reactivity:
This antibody reacts with Dlk on Flow cytometry and Immunohistochemistry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 24-11) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell with rat splenocyte immunized with Pref-1-Fc protein.
Target:
DLK/Pref-1

Documents

References

1) Suzuki, K., et al., Gastroenterology, 135, 270-281 (2008) 2) Tanimizu, N., et al., J. Cell Sci. 116, 1775-1786 (2003) 3) Kaneta, M., et al., J. Immunol. 164, 256-264 (2000) Clone 24-11 is used in the reference nunmber 1).