MBL

Anti-CD112 (Human) mAb

Product Code:
 
MBL-D175-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
TX31
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
1 / 2
2 / 2
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MBL-D175-3100 ug£248.00
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Further Information

Applications:
FCM - 5-10 ug/mL (final concentration)
Background:
CD112, also known as Poliovirus Receptor Related 2 (PRR2), is a transmembrane glycoprotein that functions as the receptor for alpha-herpes virus and pseudorabies virus entry into the cell. CD112 has been shown to be identical to Nectin-2, an adhesion protein localized to adherens junctions. CD112 is widely expressed in neuronal, endothelial, and in particular, epithelial cells, where it is found at the intercellular junctions of adjacent cells. Additionally CD112 is detected on hematopoietic progenitors expressing CD34, where it plays a role in the regulation of hematopoietic/endothelial cell interactions. At least two isoforms of CD112 mRNA have been identified.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
Gene IDs:
Human: 5819 Mouse: 19294
Immunogen Translated:
Recombinant human CD112
Reactivity:
This antibody reacts with human CD112 antigen on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone TX31) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell Sp2/0 with Wister rat lymphocyte immunized with the recombinant human CD112.
Target:
CD112

Documents

References

1) Tahara-Hanaoka, S., et al., Blood 107, 1491-1496 (2006) 2) Tahara-Hanaoka, S., et al., Int. Immunol. 16, 533-538 (2004) 3) Bottino, C., et al., J. Exp. Med. 198, 557-567 (2003) Clone TX31 is used in reference number 1) and 2).