CircuLex S100A6 ELISA Kit
Product Code:
MBL-CY-8097
MBL-CY-8097
Regulatory Status:
RUO
RUO
Application:
Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
4°C
4°C
Storage:
4°C
4°C
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| Code | Size | Price |
|---|
| MBL-CY-8097 | 96 Assays | £602.00 |
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Typical lead time: 10-14 working days.
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- Further Information
- Documents
- References
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Further Information
Alternative Names:
Calcyclin, CACY, 2A9,PRA, CaBP, 5B10
Background:
S100A6 also known as calcyclin, a small acidic protein of which molecular weighs is about 10.5 kDa,
belongs to the S100 calcium-binding protein family (1). These family members share a common S100
calcium-binding motif and are involved in several regulatory functions that include protein
phosphorylation, some enzyme activities, the dynamics of cytoskeletal components, transcription factors,
and Ca2+ homeostasis, and also cell proliferation and differentiation (2, 3).
S100A6 is most abundantly expressed in fibroblasts and epithelial cells (4) and has also been found in
some neurons, astrocytes, smooth muscle cells, cardiac myocytes, platelets and lymphocytes. S100A6 is
also expressed by osteoblasts and up-regulated markedly during osteoblast differentiation; however, its
roles in bone physiology are unknown (5). In addition, S100A6 is overexpressed in several tumor cells
with high metastatic activity, e.g. melanoma (6). Therefore S100A6 may also be involved in
tumorigenesis.
The general function of S100A6 remains unclear, but evidence suggests that it is involved in cell cycle
regulation (7, 8) and exocytosis (9, 10), and in the regulation of heat shock proteins and cytoskeletal
dynamics. Interestingly overexpression of S100A6 has also been observed in patients suffering from
Alzheimer disease or amyotrophic lateral sclerosis (11, 12).
Description:
This kit is used for the quantitative measurement of human S100A6 in cell lysate, cell culture supernatant, serum, plasma and other biological media.
Kit Components:
Microplate, 10X Wash Buffer, Dilution Buffer, Human S100A6 Standard, HRP conjugated Detection Antibody, Substrate Reagent, Stop Solution
Measurement Range:
37.5 pg/mL~24 ng/mL
Sensitivity:
11.1 pg/mL
Target:
S100A6
Documents
References
1. Heizmann, C.W., and Cox, J.A.; New perspectives on S100 proteins: a multi-functional Ca2+-, Zn2+-
and Cu2+- binding protein family. BioMetals 11, 383-397, 1998
2. Donato, R.; Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim.
Biophys. Acta 1450, 191-231, 1999
3. Donato, R.; S100: a multigenic family of calcium-modulated proteins of the EF-hand type with
intracellular and extracellular functional roles. Int. J. Biochem. Cell Biol. 33, 637-668, 2001
4. Stul?k J, ?sterreicher J, Koupilov? K, Kn??ek J, Bure? J, Jand?k P, Langr F, D?di? K, Sch?fer BW,
Heizmann CW.; Differential expression of the Ca2+ binding S100A6 protein in normal, preneoplastic
and neoplastic colon mucosa. Eur. J. Cancer 36, 1050-1059, 2000
5. Seth A, Lee BK, Qi S, Vary CP.; Coordinate expression of novel genes during osteoblast
differentiation. J. Bone Miner. Res. 15, 1683-1696, 2000
6. Weterman MA, Stoopen GM, van Muijen GN, Kuznicki J, Ruiter DJ, Bloemers HP.; Expression of
calcyclin in human melanoma cell lines correlates with metastatic behavior in nude mice. Cancer Res.
52, 1291-1296, 1992
7. Calabretta B, Battini R, Kaczmarek L, de Riel JK, Baserga R. Molecular cloning of the cDNA for a
growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. J. Biol.
Chem. 261, 12628-12632, 1986
8. Calabretta B, Venturelli D, Kaczmarek L, Narni F, Talpaz M, Anderson B, Beran M, Baserga R.;
Altered expression of G1-specific genes in human malignant myeloid cells. Proc Natl Acad Sci U S A.
83, 1495-1498, 1986
9. Okazaki K, Niki I, Iino S, Kobayashi S, Hidaka H; A role of calcyclin, a Ca2+-binding protein, on
Ca2+-dependent insulin release in the pancreatic ? cell. J. Biol. Chem. 269, 6149-6152, 1994
10. Thordarson, G., Southard, J.N., Talamantes, F.; Purification and characterization of mouse decidual
calcyclin: A novel stimulator of mouse placental lactogen-II secretion Endocrinology 129,
1257-1265, 1991
11. Boom A, Pochet R, Authelet M, Pradier L, Borghgraef P, Van Leuven F, Heizmann CW, Brion J-P. ;
Astrocytic calcium/zinc binding protein S100A6 over expression in alzheimer's disease and in
PS1/APP transgenic mice models. Biochim. Biophys. Acta 1742, 161-168, 2004
12. Hoyaux D., Boom A., Van den Bosch L., Belot N., Martin J.J., Heizmann C.W., Kiss R., Pochet R.;
S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse
model and human patients. J. Neuropathol. Exp. Neurol. 61, 736-744, 2002