Leinco Technologies

Anti-Mouse CD32/CD16 - Purified (Fc Block Antibody)

Product Code:
 
LEI-C247
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
2.4G2
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Blocking
  • Flow Cytometry
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
  • Spatial Biology
  • Western Blot (WB)
Shipping:
 
Ambient
Storage:
 
This purified antibody is stable when stored at 2-8°C. Do not freeze.
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CodeSizePrice
LEI-C247-0.5mg0.5 mg£227.00
Quantity:
LEI-C247-1.0mg1.0 mg£311.00
Quantity:
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Further Information

Antigen Distribution:
These receptors are present on B cells, monocyte/macrophages, NK cells, neutrophils, mast cells and dendritic cells.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Sorted pre-B cells
Long Description:
CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.
NCBI Gene:
1413014131
Purity:
>95% by SDS-PAGE and HPLC
Target:
CD32/CD16

References

1.) Titas, J. A. et al. (1982) J. Immunol. 133:556 2.) Rodewald, H. et al. (1992) Cell 69:139 3.) Skyberg, J. A. et al. (2020) Infection and Immunity. 88: 5 Journal Link