Leinco Technologies

Recombinant Human PD-ECGF

Product Code:
 
LEI-P252
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-P252-10ug10 ug£591.00
Quantity:
LEI-P252-50ug50 ug£1,638.00
Quantity:
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Further Information

Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in sodium phosphate (NaH2PO4) and ammonium sulphate ((NH4)2SO4)
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in sodium phosphate (NaH2PO4) and ammonium sulphate ((NH4)2SO4)
Long Description:
Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF), also known as ECGF-1, Gliostatin and TPase, is an acidic, non-glycosylated protein and member of the FGF family. It is an angiogenic factor which promotes angiogenesis in vivo and stimulates the growth and chemotaxis of a variety of endothelial cells in vitro (1). PD-ECGF is produced by placenta, platelets, liver, lung, spleen, lymph nodes, and peripheral lymphocytes, and exists mostly within producer cells. It is synthesized by fibroblasts, vascular smooth muscle cells, and a number of transformed cell lines but not endothelial cells (2). Since PD-ECGF exclusively stimulates endothelial cells and is produced also by platelets, it is likely involved in the maintenance of intact blood vessels and wound healing. It is also the key enzyme involved in the pyrimidine nucleoside salvage pathway. PD-ECGF is suggested to play an important role in tumor angiogenesis, growth, invasion and metastasis, since expression levels of PD-ECGF are elevated in many malignant solid tumors (3). It is thought to promote tumor progression possibly by preventing hypoxia-induced apoptosis. Loss-of-function mutations in the PD-ECGF gene lead to mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) (4).
NCBI Gene:
1890
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
PD-ECGF

References

1. Ishikawa, F. et al. (1989) Nature 338:557 2. Miyazono, K. et al. (1991) Prog Growth Fact. Res. 3:207 3. Akiyama, S. et al. (1993) Human Cell 6:1 4. Taanman, JW. et al. (2009) Neuromuscul. Disord. 19:151