Leinco Technologies

Anti-Human CARMA1

Product Code:
 
LEI-C1217
Product Group:
 
Primary Antibodies
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ambient
Storage:
 
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-C1217-20ug20 ug£199.00
Quantity:
LEI-C1217-0.1mg0.1 mg£591.00
Quantity:
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This product comes from: US.
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Further Information

Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:C1231
Long Description:
CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.1 CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.2,3 Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I/K complex, thereby regulating activation of the NF-κB transcription factor.5 Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.6
Target:
CARMA1

References

1. Fanning, AS. and Anderson, JM. (1999) Curr. Opin. Cell Biol. 11:432-9. 2. Gaide, O. et al. (2001) FEBS Lett. 496:121-7. 3. Bertin, J. et al. (2001) J. Biol. Chem. 276:11877-82. 4. McAllister-Lucas, LM. et al. (2001) J. Biol. Chem. 276:30589-97.