Leinco Technologies

Recombinant Human PDGF-AB

Product Code:
 
LEI-P128
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-P128-10ug10 ug£489.00
Quantity:
LEI-P128-50ug50 ug£1,274.00
Quantity:
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This product comes from: US.
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  • Further Information
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Further Information

Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Long Description:
Platelet-derived growth factor AB (PDGF-AB) is a heterodimeric1 non-glycosylated polypeptide isomer of PDGF.2 The biological effects of PDGF are mediated by cell surface alpha and beta PDGF receptors, which, as a result of ligand binding, undergo dimerization.3 PDGF-AB interaction with the alpha PDGF receptor induces conformational changes in the ligand or receptor that facilitates efficient recruitment of beta PDGFR by this PDGF isoform.4 However, PDGF-AA is not likely to be physiologically significant activators of cells unless the cells express PDGFR alpha.5 PDGF-AB may promote wound healing by stimulating extracellular matrix synthesis, e.g. collagen. It may also play a role in scar formation through collagen deposition.6
NCBI Gene:
51545155
Purity:
>97% by SDS Page and analyzed by silver stain.
Target:
PDGF-AB

References

1. Helden, CH. et al. (1988) J Biol Chem. 263: 16493 2. Canalis, E. et al. (1994) Endocrinology 134: 2541 3. Giese, NA. et al. (1993) J Biol Chem. 268: 3625 4. Aaronson, SA. et al. (1991) J Biol Chem. 266: 20232 5. Bowen-Pope, DF. et al. (1993) J Biol Chem. 268: 4473 6. Xu, M. et al. (2000) Chinese Journal of Plastic Surgery and Burns 16: 78