Leinco Technologies

Anti-Human HLA-DQ (MHC Class II) - FITC

Product Code:
 
LEI-H137
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1a3
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ambient
Storage:
 
This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
LEI-H137-50ug50 ug£152.00
Quantity:
LEI-H137-100ug100 ug£209.00
Quantity:
LEI-H137-200ug200 ug£303.00
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: US.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Show All

Further Information

Antigen Distribution:
HLA-DQ is expressed on antigen-presenting cells, including macrophages, monocytes, DCs, and B cells, and activated T cells.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
Fluorescein (FITC)
Format:
This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
HLA-DQ antibody, clone 1a3, recognizes the major histocompatibility complex (MHC) class II molecule Human Leukocyte Antigen - DQ isotype (HLA-DQ). MHC class II is constitutively expressed on human professional antigen-presenting cells (APCs), including macrophages/monocytes, dendritic cells (DCs), and B cells, and is induced on T cells upon activation2. HLA-DQ consists of two transmembrane proteins, a 35 kDa α (heavy) chain and 29 kDa β (light) chain3 encoded by the HLA-DQA1 and HLA-DQB1 genes, respectively, located in the HLA complex of chromosome 6. The N-terminal α1 and β1 domains form the antigen-binding groove, which binds 13-25 aa peptides derived from exogenous antigens4. On APCs, MHC class II plays a critical role in the adaptive immune response by presenting phagocytosed antigens to helper CD4 T cells. The T cell receptor (TCR)/CD3 complex of CD4 T cells interacts with peptide-MHC class II, which induces CD4 T cell activation leading to the coordination and regulation of other effector cells. CD4 molecules also bind to MHC class II, which helps augment TCR signaling5. It has also been demonstrated that MHC class II express on activated T cells are capable of antigen presentation6 and can transduce signals into T cells, enhancing T cell proliferation and activity7. Specific alleles of HLA-DQ are associated with autoimmune diseases, including celiac disease8 and type 1 diabetes9, and graft-versus-host disease10.
NCBI Gene:
3122
Target:
HLA-DQ Monomorphic

References

1. Shookster L, et al. (1987) Hum Immunol. 20(1):59-70 2. Holling TM, Schooten E, van Den Elsen PJ. (2004) Hum Immunol. 65(4):282-90 3. Mitaksov V, Fremont DH. (2006) J Biol Chem. 281(15):10618-25 4. Wieczorek M, et al. (2017) Front Immunol. 8:292 5. Artyomov MN, et al. (2010) Proc Natl Acad Sci USA. 107(39):16916-16921 6. Barnaba V, et al (1994) Eur J Immunol. 24(1):71-5 7. Di Rosa F, et al. (1993) Hum Immunol. 38(4):251-60 8. Casta?o L, et al. (2004) J Pediatr Gastroenterol Nutr. 39:80?84 9. Cucca F, et al. (1993) Hum Immunol. 37:85 ?94 10. Petersdorf EW, (1996) Proc Natl Acad Sci USA. 93(26):15358-63