TargetMol

Kasugamycin hydrochloride hydrate

Product Code:
 
TAR-T8404
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8404-200mg200mg£94.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8404-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Kasugamycin hydrochloride hydrate(Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct competition with initiator transfer RNA
CAS:
200132-83-8
Formula:
C14H28ClN3O10
Molecular Weight:
433.84
Pathway:
Microbiology/Virology
Purity:
1
SMILES:
O.Cl.C[C@H]1O[C@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]2O)[C@@H](N)C[C@@H]1NC(=N)C(O)=O
Target:
Antibacterial; Antibiotic

References

Schuwirth BS, et al. Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol. 2006 Oct;13(10):879-86. Christian Lange , Matthias Lehr , Karolin Zerulla.Effects of Kasugamycin on the Translatome of Escherichia Coli.PLoS One. 2017 Jan 12;12(1):e0168143. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8.