TargetMol

Dasatinib hydrochloride

Product Code:
 
TAR-T22303
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22303-50mg50mg£101.00
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TAR-T22303-100mg100mg£114.00
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TAR-T22303-1mL1 mL * 10 mM (in DMSO)£116.00
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Further Information

Bioactivity:
Dasatinib hydrochloride is a highly ATP competitive, potent, orally active inhibitor of dual Src/Bcr-Abl(with Ki values of 16 pM and 30 pM for Src and Bcr-Abl, respectively), and has potent antitumor activity.
CAS:
854001-07-3
Formula:
C22H27Cl2N7O2S
Molecular Weight:
524.47
Pathway:
Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; Angiogenesis
Purity:
0.98
SMILES:
Cl.Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Target:
Bcr-Abl; Src; c-Kit

References

Lombardo LJ, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays