TargetMol

Compound 48/80 trihydrochloride

Product Code:
 
TAR-T13623
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13623-5mg5mg£110.00
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Quantity:
TAR-T13623-1mL1 mL * 10 mM (in DMSO)£149.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Compound 48/80 trihydrochloride is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. It inhibits phosphatidylinositol-specific phospholipase C activity from human platelets. It is also a histamine releaser and a mast cell degranulator.
CAS:
848035-21-2
Formula:
C32H48Cl3N3O3
Molecular Weight:
629.1
Pathway:
Metabolism
Purity:
0.98
SMILES:
Cl.Cl.Cl.CNCCc1ccc(OC)c(Cc2cc(CCNC)cc(Cc3cc(CCNC)ccc3OC)c2OC)c1
Target:
Phospholipase

References

1. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. 2. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. 3. Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80.