TargetMol

Paromomycin Sulfate

Product Code:
 
TAR-T1104
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1104-500mg500mg£103.00
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Further Information

Bioactivity:
Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.
CAS:
1263-89-4
Formula:
C23H47N5O18S
Molecular Weight:
713.71
Pathway:
Microbiology/Virology
Purity:
0.9973
SMILES:
OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Target:
Antibacterial; Antibiotic; Parasite

References

1. Davidson RN, et al. ParomomycinTrans R Soc Trop Med Hyg, 2009, 103(7), 653-660. 2. Simon L. Croft, et al. Clin Microbiol Rev, 2006, 19(1), 111-126 3. Li Zhu, Ruonan Liu, Tangrong Liu, Xuan Zou, Zhe Xu, Huashi Guan. A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis. 2019 Feb 5;164:520-527.