TargetMol

Dimethyl fumarate

Product Code:
 
TAR-T0492
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0492-500mg500mg£107.00
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Further Information

Bioactivity:
Dimethyl fumarate, a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
CAS:
624-49-7
Formula:
C6H8O4
Molecular Weight:
144.126
Pathway:
Immunology/Inflammation; NF-κb; Proteases/Proteasome; Autophagy; Metabolism; Microbiology/Virology
Purity:
0.9051
SMILES:
COC(=O)C=CC(=O)OC
Target:
Reactive Oxygen Species; HIV Protease; Nrf2; Endogenous Metabolite; Autophagy

References

1. Albrecht P, et al. J Neuroinflammation,2012, 9, 163. 2. Peng H, et al. J Biol Chem,2012, 287(33), 282017-28026. 3. Meili-Butz S, et al. Eur J Pharmacol,2008, 586(1-3), 251-258. 4. Cross SA, et al. J Immunol,2011, 187(10), 52015-5025. 5. Jing X, et al. Neuroscience,2015, 286, 131-140. 6. Li Y, et al. Dimethyl fumarate accelerates wound healing under diabetic condition. J Mol Endocrinol. 2018 Jul 23. pii: JME-18-0102. 7. Wang Y, Ma H, Huang J, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors[J]. European Journal of Medicinal Chemistry. 2020: 113030.