TargetMol

DS-437

Product Code:
 
TAR-T15169
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
CAS:
1674364-87-4
Formula:
C15H23N7O4S
Molecular Weight:
397.45
Purity:
0.98
SMILES:
CCNC(=O)NCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12

References

1. Smil D, et al. Discovery of a Dual PRMT5-PRMT7 Inhibitor.ACS Med Chem Lett.?2015?Mar 2;6(4):408-12. 2. Nagai Y, et al. PRMT5?Associates?With the?FOXP3?Homomer?and When?Disabled?Enhances?Targetedp185erbB2/neu?Tumor?Immunotherapy.Front Immunol.?2019 Feb 8;10:174.