TargetMol

1G244

Product Code:
 
TAR-T14005
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14005-5mg5mg£115.00
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Quantity:
TAR-T14005-10mg10mg£142.00
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TAR-T14005-25mg25mg£213.00
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TAR-T14005-50mg50mg£303.00
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TAR-T14005-100mg100mg£450.00
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Quantity:
TAR-T14005-500mg500mg£863.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[1][2].
CAS:
847928-32-9
Formula:
C29H30F2N4O2
Molecular Weight:
504.582
Pathway:
Proteases/Proteasome|Ubiquitination
Purity:
0.98
SMILES:
N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1
Target:
Proteasome

References

1. Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9(1):18094. 2. Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.