TargetMol

CMP-5

Product Code:
 
TAR-T10850
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T10850-100mg100mgEnquire
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Further Information

Bioactivity:
CMP-5 is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.
CAS:
880813-42-3
Formula:
C21H21N3
Molecular Weight:
315.42
Purity:
0.98
SMILES:
CCn1c2ccccc2c2cc(CNCc3ccccn3)ccc12

References

1. Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. 2. Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017 Feb 15;198(4):1439-1451.