TargetMol

NCGC00092410

Product Code:
 
TAR-T40544
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40544-1mg1mg£103.00
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TAR-T40544-5mg5mg£149.00
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TAR-T40544-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T40544-10mg10mg£201.00
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TAR-T40544-25mg25mg£326.00
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TAR-T40544-50mg50mg£464.00
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TAR-T40544-100mg100mg£653.00
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TAR-T40544-500mg500mg£1,291.00
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Further Information

Bioactivity:
NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC 50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease.
CAS:
442898-34-2
Formula:
0
Molecular Weight:
0
Pathway:
Metabolism
Purity:
0.98
SMILES:
0
Target:
Glucosidase

References

Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7.