TargetMol

RN-9893 (hydrochloride)

Product Code:
 
TAR-T37321
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37321-5mg5mg£850.00
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TAR-T37321-50mg50mg£1,661.00
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TAR-T37321-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors).1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively). RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays).
CAS:
2109450-40-8
Formula:
C21H23F3N4O5S.HCl
Molecular Weight:
537
Purity:
0.98
SMILES:
FC(F)(F)C1=CC=C(C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)=O)C([N+]([O-])=O)=C1.Cl

References

Wei, Z.L., Nguyen, M.T., O'Mahony, D.J., et al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg. Med. Chem. Lett. 25(18), 4011-4015 (2015).