TargetMol

S 14506 HCl

Product Code:
 
TAR-T28637
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28637-5mg5mg£850.00
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Quantity:
TAR-T28637-50mg50mg£1,661.00
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Quantity:
TAR-T28637-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
S 14506 HCl is a highly potent selective 5-HT1A receptor full agonist, pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively.
CAS:
135722-25-7
Formula:
C24H27ClFN3O2
Molecular Weight:
443.95
Purity:
0.98
SMILES:
O=C(NCCN1CCN(C2=C3C=C(OC)C=CC3=CC=C2)CC1)C4=CC=C(F)C=C4.[H]Cl

References

1. Milligan G, Kellett E, Dacquet C, Dubreuil V, Jacoby E, Millan MJ, Lavielle G, Spedding M. S 14506: novel receptor coupling at 5-HT(1A) receptors. Neuropharmacology. 2001 Mar;40(3):334-44. PubMed PMID: 11166326. 2. Lima L, Laporte AM, Gaymard C, Spedding M, Moca?r E, Hamon M. Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J Neural Transm (Vienna). 1997;104(10):1059-75. PubMed PMID: 9503258. 3. Schreiber R, Brocco M, Gobert A, Veiga S, Millan MJ. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. PubMed PMID: 7705455. 4. Protais P, Chagraoui A, Arbaoui J, Moca?r E. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77. PubMed PMID: 7698199.