TargetMol

EPZ011989 trifluoroacetate

Product Code:
 
TAR-T2435L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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TAR-T2435L-100mg100mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
EPZ011989 TFA is an effective, selective, orally bioavailable EZH2 inhibitor.
CAS:
1598383-41-5
Formula:
C39H53F6N5O8
Molecular Weight:
833.87
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCN([C@H]1CC[C@@H](CC1)N(C)CCOC)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#CCN1CCOCC1

References

1. Gardner EE, Lok BH, Schneeberger VE, Desmeules P, Miles LA, Arnold PK, Ni A, Khodos I, de Stanchina E, Nguyen T, Sage J, Campbell JE, Ribich S, Rekhtman N, Dowlati A, Massion PP, Rudin CM, Poirier JT. Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis. Cancer Cell. 2017 Feb 13;31(2):286-299. doi: 10.1016/j.ccell.2017.01.006. PubMed PMID: 28196596; PubMed Central PMCID: PMC5313262. 2. Campbell JE, Kuntz KW, Knutson SK, Warholic NM, Keilhack H, Wigle TJ, Raimondi A, Klaus CR, Rioux N, Yokoi A, Kawano S, Minoshima Y, Choi HW, Porter Scott M, Waters NJ, Smith JJ, Chesworth R, Moyer MP, Copeland RA. EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity. ACS Med Chem Lett. 2015 Mar 4;6(5):491-5. doi: 10.1021/acsmedchemlett.5b00037. eCollection 2015 May 14. PubMed PMID: 26005520; PubMed Central PMCID: PMC4434464.