TargetMol

XY018

Product Code:
 
TAR-T24213
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T24213-100mg100mgEnquire
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Further Information

Bioactivity:
XY 018 is a RORγ antagonist. It also suppresses androgen receptor expression in prostate cancer cell lines and inhibits the growth of tumors in androgen receptor-positive xenograft models.
CAS:
1873358-87-2
Formula:
C23H15F7N2O4
Molecular Weight:
516.372
Purity:
0.98
SMILES:
OC(c1ccc(c(F)c1)-c1ccc(NC(=O)Cc2ccccc2[N+]([O-])=O)cc1)(C(F)(F)F)C(F)(F)F

References

1. Wang et al (2016) ROR-? drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat.Med. 22 488 PMID: 27019329 2. Ndagi et al (2016) Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for ROR? protein. J.Biomol.Struct.Dyn. 36 1